Akne in verschiedenen Lebensphasen: ähnliche Klinik, unterschiedliche Konsequenzen

Zusammenfassung

Akne ist eine häufige Erkrankung mit hoher Prävalenz unter Jugendlichen („Pubertätsakne“). Jedoch gibt es weitere Sonderformen, die vor allem im Säuglings- und Kindesalter auftreten. Hierzu gehören Acne neonatorum, Acne juvenilis sowie Akne der mittleren Kindheit. Die Krankheit wird von endogenen (genetische Disposition, Androgene, Wachstumshormone) und exogenen (Propionibacterium acnes, Ernährungsgewohnheiten, mechanische Irritation) Faktoren moduliert. Pathogenetische Hauptfaktoren sind gesteigerte Talgproduktion, follikuläre Differenzierungsstörungen und perifollikuläre Entzündungsvorgänge. Für die Therapie stehen wirksame topische und systemische Medikamente zur Verfügung. Je nach Lebensalter des Betroffenen, werden unterschiedliche Behandlungsverfahren und Vorgehensweisen empfohlen.

Abstract

Acne typically is associated with adolescence and young adulthood. However, there are other special forms that occur especially in infancy and childhood. These include acne neonatorum, acne juvenilis as well as midchildhood acne. The disease is modulated by endogenous (genetic disposition, androgens, growth hormones) and exogenous (propionibacterium acnes, dietary habits, mechanical irritation) factors. Main pathogenetic factors are increased sebum production, follicular differentiation disorders and perifollicular inflammatory processes. A broad range of acne treatments are available and have been shown to be safe and effective. Depending on the age of the person affected, different treatment methods and procedures are recommended.

Schlüsselwörter

Akne - Pathogenese - Säugling - Kinder - Therapie

Key words

Acne - pathogenesis - infancy - childhood - treatment

• Literaturverzeichnis

• 1 Admani S, Barrio VR.. Evaluation and treatment of acne from infancy to preadolescence.. Dermatol Ther 2013; 26: 462-466
• 2 Nast A, Bayerl C, Borelli C. et al. S2k-Leitlinie zur Therapie Akne.. JDDG 2010; Suppl 2 S1-559
• 3 Antoniou C, Dessinioti C, Stratigos AJ, Katsambas AD.. 2009; Clinical and therapeutic approach to childhood acne: an update.. Pediatr. Dermatol. 26: 373-80
• 4 Degitz K, Ochsendorf F.. Akne.. JDDG 2017; 15: 709-722
• 5 Bolognia JL, Schaffer JV, Cerroni L.. Dematology. 4^th ed. Elsevier 2018; 593-594
• 6 Eichenfield LF, Krakowski AC, Piggott C. et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne.. Pediatrics 2013; 131 Suppl 3 S163-186
• 7 Goulden V, McGeown CH, Cunliffe WJ.. The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals.. Br J Dermatol 1999; 141: 297-300
• 8 Hütten M, Baron JM, Ott H.. Systemic retinoid therapy in severe acne infantum.. Hautarzt 2008; 59: 454-457
• 9 Jones-Caballero M, Chren MM, Soler B. et al. Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment.. JEADV 2007; 21: 219-226
• 10 Melnik B.. Acne vulgaris. Role of diet.. Hautarzt 2010; 61: 115-125
• 11 Nast A, Dréno B, Bettoli V. et al. European evidence-based (S3) guideline for the treatment of acne – update 2016 – short version.. JEADV 2016; 30: 1261-1268
• 12 Ochsendorf F.. Pathogenese und Therapie der Akne: Aktuelle Aspekte.. Akt Dermatologie 2007; 33: 137-141
• 13 Plewig G, Braun-Falco O, Ruzicka T. et al. Braun-Falco’s Dermatologie, Venerologie und Allergologie. 7^th ed. Berlin; Springer: 2018: 1317-1318
• 14 Qin L-Q, He K, Xu J-Y.. Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review.. Int J Food Sci Nutr 2009; 60 Suppl 7 330-340
• 15 Rahaman SMA, De D, Handa S. et al. Association of insulin-like growth factor (IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity.. J Am Acad Dermatol 2016; 75: 768-773
• 16 Samycia M, Lam JM.. Infantile acne.. CMAJ Can Med Assoc J 2016; 188: 17-18E540
• 17 Schäfer T, Kahl C, Rzany B.. Epidemiology of acne.. JDDG 2010; 8 Suppl 1 S4-6
• 18 Serna-Tamayo C, Janniger CK, Micali G, Schwartz RA.. Neonatal and infantile acne vulgaris: an update.. Cutis 2014; 94: 13-16
• 19 Smith RN, Mann NJ, Braue A. et al. The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial.. J Am Acad Dermatol 2007; 57: 247-256
• 20 Tasli L, Turgut S, Kacar N. et al Insulin-like growth factor-I gene polymorphism in acne vulgaris.. JEADV 2013; 27: 254-257
• 21 Zouboulis CC.. Moderne Aspekte der Aknepathogenese.. Akt Dermatol 2006; 32: 296-302